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2015). These reports, taken jointly, counsel that, Though a immediate activation of GPR55 or PPAR‐α occurs, PEA can deliver its anti‐inflammatory motion in the intestine also through oblique activation of CB1 and CB2 receptors, most likely due to the flexibility of this compound to potentiate the motion of endocannabinoids at these receptors.I
Of Observe is, due to PEA’s higher lipophilicity, micronized or ultra-micronized formulations are considered for being extra very easily absorbable, with much more favorable pharmacokinetics and bigger efficacy. While There's some proof supporting this principle, there is still no proof of the superiority of micronized PEA [sixteen].This is a pre
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